India Globalization Capital, Inc. (IGC)

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Re: India Globalization Capital, Inc. (IGC)

Postby QualityStocks » Tue Jun 06, 2017 4:29 pm

India Globalization Capital, Inc. (NYSE: IGC) Targets Human and Veterinary Epilepsy with Innovative Cannabinoid Therapy

With about 50 million people affected worldwide, drug-resistant epilepsy, or refractory epilepsy, is a very serious condition for which a medical solution has not yet been found, but the therapeutic benefits of phytocannabinoid-based therapies for seizures have been coming under increased scrutiny lately. There is mounting evidence that cannabinoid extracts, and in particular cannabidiol (CBD), can have a positive impact on epilepsy patients and alleviate seizures, as indicated by recent research. Companies such as India Globalization Capital, Inc. (NYSE MKT: IGC) are at the forefront of discovering cannabinoid-based epilepsy treatments for humans and animals alike, by developing innovative formulations that can change the paradigm of seizure therapies.

Although stories of cannabis benefits for seizure patients have been around for more than a century, the interest in marijuana has increased significantly in the last few years due to the growing legalization movement. At the moment, marijuana is legal for medical or recreational consumption in almost 30 states, and supporters of legalization hope the substance will eventually be allowed nationwide. There is also hope that widespread legalization will eventually force the federal government to declassify marijuana as a Schedule I drug, a classification that currently stands in the way of the cannabis industry’s potential development mostly by limiting businesses’ access to banking and financial solutions.

Most research into the effects of cannabis on epilepsy has focused on CBD, the most abundant non-psychoactive cannabinoid in the marijuana plant. According to the American Epilepsy Society (http://nnw.fm/C8CLn), recent studies have indicated that CBD was successfully used to reduce the intensity and frequency of seizures in children with refractory epilepsy. Multiple other studies have indicated similar results, in particular a dramatic drop in the number of seizures reported by patients who were given CBD-based treatments, according to the Epilepsy Foundation (http://nnw.fm/Lo5oS). The same effects were reported for CBD use to treat veterinary epilepsy in multiple species, most notably in cats and dogs. The second most abundant cannabinoid extract, tetrahydrocannabinol (THC), was also found to have a positive impact on epilepsy patients, but it is not as easily tolerated due to its psychotropic properties.

Maryland-based IGC is developing innovative CBD-based therapies targeting both human and veterinary epilepsy, as well as other types of seizures. The company has already filed for a U.S. patent for the formulation, administered via different delivery technologies, and has plans to start metabolic profiling and apply to the Food and Drug Administration to start clinical trials. One of its product candidates targeting seizures in animals, IGC-502, is scheduled to begin clinical trials this year.

In addition to seizures, IGC has developed a pipeline of cannabinoid-based therapies targeting various major disorders, including eating disorders and neuropathic pain. The company is becoming a leader in the use of combination therapies that pair cannabis extracts with other traditional medications for the treatment of different conditions, positioning itself as a unique and interesting investment option on the ever-growing medical marijuana market.

For more information, visit the company’s website at www.IGCinc.us
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Re: India Globalization Capital, Inc. (IGC)

Postby QualityStocks » Wed Jun 07, 2017 4:19 pm

NetworkNewsBreaks – India Globalization Capital, Inc. (NYSE: IGC) Pursues Clinical Trials of Cannabis-Based Combination Therapies with Assistance of New Advisor

India Globalization Capital (NYSE MKT: IGC) recently named Craig Cheifetz, M.D. as an advisor to assist the company with its clinical trials in microbiology, immunology, neuroscience and biotechnology. IGC CEO Ram Mukunda stated in a news release that the company looks forward to Dr. Cheifetz’s contributions as IGC moves forward in the development of unique cannabis combination therapies. “The company anticipates clinical trials in 2017 for several indications, including pain, a huge market. IGC has already filed for six patents in areas such as eating disorders and epilepsy, in addition to pain. It is working on several more filings for indications including depression, Alzheimer’s and Parkinson’s disease. Its lead candidate is IGC-501, and it has filed patents for the candidate in the United States, Canada and Europe.”
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Re: India Globalization Capital, Inc. (IGC)

Postby QualityStocks » Mon Jun 12, 2017 5:14 pm

NetworkNewsBreaks – India Globalization Capital, Inc. (NYSE: IGC) Becomes Exclusive Licensee of Cannabis-Based Treatment for Alzheimer’s Disease

India Globalization Capital, Inc. (NYSE MKT: IGC), a developer of cannabis-based therapies to treat a variety of life-altering conditions, this morning announced its entry into a definitive license agreement with the University of South Florida that makes the company the exclusive licensee of the U.S. patent filing entitled ‘THC as a Potential Therapeutic Agent for Alzheimer’s Disease’. If the patent filing is granted and proven, IGC anticipates that it could create a “significant therapeutic pathway” in the Alzheimer’s disease market, which is expected to record direct costs in excess of $450 billion annually in the next 12 years. “Securing this licensing agreement from the University of South Florida represents a major turning point for IGC as we now look to prepare several of our key products for clinical trials,” Ram Mukunda, CEO of IGC, stated in the news release. “We have worked hard to assemble a strong development team and a primary pipeline of four major products addressing large markets and possible blockbuster indications utilizing cannabis-based therapies. We are putting the finishing touches on our products, which may include filing additional patents, and we very much expect to start pursuing clinical trials for our Alzheimer’s product and others this year.”
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Re: India Globalization Capital, Inc. (IGC)

Postby QualityStocks » Thu Jun 15, 2017 3:51 pm

Pharmaceutical Leaders Pave the Way to New Alzheimer’s Treatments

NetworkNewsWire Editorial Coverage: Alzheimer’s disease is a devastating brain disorder that now affects about 5.3 million Americans, accounting for one in nine people over the age of 65, according to the Alzheimer’s Association. One in three seniors die with the disease or another form of dementia, and, while treatments to slow or stop the disease’s progression have been lacking, several pharmaceutical companies are working to change that. India Globalization Capital, Inc. (NYSE: IGC) (IGC Profile), which has products that are backed by data of cannabis-based combination therapies to treat Alzheimer’s, pain, seizures and a host of neurological and oncological issues, is lined up with Biogen, Inc. (NASDAQ: BIIB), Anavex Life Sciences Corp. (NASDAQ: AVXL), Axovant Sciences Ltd. (NASDAQ: AXON) and AC Immune SA (NASDAQ: ACIU) to develop medications they hope will yield promising results in treating a difficult and hard to treat illness.

The cost to the U.S economy from Alzheimer’s disease is estimated at $236 billion, including the costs of caring for individuals with the illness. Without effective treatments, the economic impact will continue to climb.

While industry behemoths like Pfizer (NYSE: PFE) and Novartis (NYSE: NVS) are obvious contenders, India Globalization Capital (IGC) is the first cannabis pharmaceutical company to focus on Alzheimer’s disease. While there are more than a dozen publicly traded cannabis pharmaceutical stocks on the market, most of them with market caps much larger than IGC’s $12 million, IGC is so far the only one to apply its cannabis-therapies to the treatment of Alzheimer’s.

IGC is aggressively advancing its unique position, and earlier this week announced (http://nnw.fm/3QaWV) that it has acquired the exclusive rights to a THC-based treatment for Alzheimer’s, moving the company one step closer to clinical trials for its Alzheimer’s product.

Under a definitive license agreement with the University of South Florida, IGC is the exclusive licensee of a patent filing for the use of tetrahydrocannabinol (THC) as a potential therapeutic agent for the disease. The patent, entitled “THC as a Potential Therapeutic Agent for Alzheimer’s Disease,” claims discovery of a new pathway in which low doses of THC bind to amyloid beta plaques and prevent those plaques from aggregating on neurons, which is what occurs in Alzheimer’s disease and causes cognitive decline.

Here’s why the application of THC (tetrahydrocannabinol), which is the psychoactive compound found in cannabis, is so exciting for the future of Alzheimer’s treatment. THC has several known molecular pathways by which it interacts with the body. Numerous studies have shown that low doses of THC can slow the production of neural plaques (considered a key contributor to the progression of Alzheimer’s), as well as decrease inflammation, prevent cell death and stimulate cell growth.

The acquisition of IGC’s new patent filing provides another layer of protection for the company’s proprietary formulation of IGC-AD1, which includes low-doses of THC and is intended to disrupt the buildup of amyloid beta plaques and relieve some of the worst symptoms of Alzheimer’s.

If the patent is granted, and it works, IGC will become the owner of a major therapeutic pathway for THC interaction with the body, with significant potential in treating this condition.

“Securing this licensing agreement from the University of South Florida represents a major turning point for IGC as we now look to prepare several of our key products for clinical trials,” IGC CEO Ram Mukunda stated in the press release. “We have worked hard to assemble a strong development team and a primary pipeline of four major products addressing large markets and possible blockbuster indications utilizing cannabis-based therapies. We are putting the finishing touches on our products, which may include filing additional patents, and we very much expect to start pursuing clinical trials for our Alzheimer’s product and others this year.”

IGC’s drug development pipeline also includes cannabinoid therapy that targets human and veterinary epilepsy (http://nnw.fm/eW8gb). The company is developing numerous cannabis-based therapies, with a potential international market reach.

There are some other companies working on Alzheimer’s with very large valuations, with IGC bringing the potential benefits of cannabis to bear on the disease.

Biogen (BIIB) has developed and tested aducanumab, a drug that helps eliminate beta amyloid, a sticky plaque found in the brain of Alzheimer’s patients. The antibody binds to the plaque, which has the potential to slow the progression of symptoms such as memory loss, confusion, trouble finding words, decreases in judgement, and changes in mood and personality. Phase 1 clinical trials included 165 patients, concluding that high doses of the drug decreased the level of amyloid plaque in the brain, as viewed using positron emission tomography. Scientists noted the slowing of the progression of memory loss in these patients as well.

Another company focused on the development of innovative therapies for Alzheimer’s, other central nervous system diseases (CNS) and various types of cancer, is New York-based Anavex Life Sciences (AVXL). The company’s lead product candidate, ANAVEX™ 2-73, is an oral drug currently in phase 2a clinical trials for Alzheimer’s, and is also being tested to Parkinson’s and other CNS diseases. Phase 1 trials for ANAVEX™ 2-73 were completed with encouraging results attesting to the compound’s potential to halt or even reverse the course of Alzheimer’s, as well as with an indication of other anticonvulsant, neuroprotective and antidepressant properties. A phase 2 placebo-controlled trial is also underway to determine ANAVEX™2-73 effects on Rett Syndrome, while a separate trial is being conducted for Parkinson’s disease. In addition to ANAVEX™2-73, the company is developing several other products targeting various symptoms and effects of Alzheimer’s.

Clinical studies are also underway for Axovant Sciences’ (AXON) lead product candidate, Intepirdine (RVT-101), and its effects on Alzheimer’s, dementia and Lewy Body Dementia. The Mindset study for Alzheimer’s is a phase 3 international, double-blind, multi-center, placebo-controlled clinical trial that aims to assess the tolerability, safety and efficacy of the drug for mild and moderate cases of Alzheimer’s. If the trials are successful, the therapy will be approved for commercialization across Europe and the United States. Phase 2 studies are being conducted to evaluate the product’s performance for dementia. A novel glycopyrrolate and cholinesterase combination is also being developed for Alzheimer’s and Lewy Body Dementia and is currently in phase 1 trials.

One of the world’s largest Alzheimer’s treatment pipelines is being developed by Swiss-based AC Immune SA (ACIU). The company is working on seven therapeutic and three diagnostic products in various stages of clinical trials, with the potential to significantly improve treatment and even prevent Alzheimer’s and other neurodegenerative diseases. All of AC Immune’s therapies were discovered and developed via the company’s proprietary Morphomer™ and SupraAntigen™ technology platforms. The lead product candidate, an anti-Abeta antibody called Crenezumab with treatment and prevention potential, is currently undergoing phase 3 clinical trials, in collaboration with Roche Holding AG (OTC: RHHBY) subsidiary, Genentech.

The focus on Alzheimer’s of so many biopharmaceutical companies is understandable, given the prevalence of this condition. In May 2017, Congress signed into law a $400 million increase for Alzheimer’s research funding at the National Institutes of Health (NIH) in the fiscal year 2017 budget, marking the second consecutive year that Congress has approved a “historic” funding increase for the disease.

This move demonstrates the urgency for the more than 5 million Americans living with the disease – a number that’s forecast to increase to 16 million by 2050 – and highlights the value of the lineup of companies working to advance their efforts for a cure.

For more information on India Globalization Capital visit India Globalization Capital (IGC)
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Re: India Globalization Capital, Inc. (IGC)

Postby QualityStocks » Tue Aug 01, 2017 4:51 pm

NetworkNewsBreaks – India Globalization Capital, Inc. (NYSE: IGC) Adds Dr. Chuanhai Cao to Medical Research Team

India Globalization Capital, Inc. (NYSE MKT: IGC), a developer of cannabis-based therapies to treat a variety of life-altering conditions, this morning announced that Dr. Chuanhai Cao has joined its medical research team as a key advisor. “The addition of Dr. Cao will accelerate IGC’s efforts to move its Alzheimer’s product Hyalolex to clinical trials,” Ram Mukunda, CEO of IGC, noted in the news release. “Dr. Cao is a dynamic force in cannabis related therapies for Alzheimer’s disease. Dr. Cao has one co-inventor patent that has been approved for medical trials, and another patent that is currently being worked on for an Investigational New Drug (IND) application with the FDA. Dr. Cao is the perfect researcher to assist us in moving our THC-based Alzheimer’s treatment into trials and potentially into a blockbuster product.” Cao currently serves as associate professor of pharmaceutical sciences at the University of South Florida’s College of Pharmacy. Additionally, he has joint appointments as associate professor at USF’s Department of Neurology at the College of Medicine and the Department of CMMB at the College of Arts and Sciences.
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Re: India Globalization Capital, Inc. (IGC)

Postby QualityStocks » Tue Oct 03, 2017 5:32 pm

NetworkNewsBreaks – India Globalization Capital (NYSE: IGC) Demonstrates Potential in Alzheimer’s Treatment Market

In response to compelling recent data, India Globalization Capital, Inc. (NYSE MKT: IGC) announced it has made a highly significant novel breakthrough in treating Alzheimer’s disease with tetrahydrocannabinol (THC)—an advancement that could potentially bring much-needed relief to Alzheimer’s sufferers. A recent IGC press release (http://nnw.fm/VlXb3) gave an update on in vitro data that has been compiled from genetically engineered cell lines in an Alzheimer’s disease model, demonstrating that, at varying THC concentrations, the aggregation of Aβ protein (the buildup of which has been linked to causing Alzheimer’s) decreases by up to 40 percent. An article further discussing this reads: “IGC stands to benefit in two ways: first, by taking IGC-ADI down the regular FDA route as both a prophylactic and a therapeutic; and second, as a food supplement to be sold in medical dispensaries. The FDA approach to a product labeled as a ‘drug’ is different to one classified as a ‘supplement.’ A drug is considered unsafe until proven otherwise by clinical trials, while a supplement, defined by the Dietary Supplement Health and Education Act (DSHEA) as food, is considered to be prima facie safe. This binal approach allows IGC to secure market share in the medical dispensary segment while IGC-AD1, named Hyalolex, works its way through the FDA approval process.”
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