Advaxis, Inc. (ADXS)

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Advaxis, Inc. (ADXS)

Postby QualityStocks » Wed Dec 05, 2012 4:52 pm

Advaxis is a clinical-stage biotechnology company developing the next-generation of immunotherapies for cancer and infectious diseases. The company’s immunotherapies are based on a novel platform technology that uses live, bio-engineered bacteria to secrete an antigen/adjuvant fusion protein that redirects the powerful immune response all human beings have to fight off cancer and disease.

The company has more than fifteen distinct constructs in various stages of development, all of which are involved in strategic collaborations with recognized centers of excellence such as: the National Cancer Institute, Cancer Research – UK, the Wistar Institute, the University of Pennsylvania, the University of British Columbia, the Karolinska Institutet, and others.

Advaxis’ lead construct, ADXS-HPV, is currently in Phase 2 clinical development for recurrent/refractory and advanced cervical cancer, CIN 2/3, and HPV caused head and neck cancers. This important construct was selected as the Best Therapeutic Vaccine (approved or in development) at the 5th Annual Vaccine Industry Excellence (ViE) Awards by the vaccine industry and the journal Expert Reviews of Vaccines.

The estimated global market for immunotherapies is projected to exceed $37.2B by 2012, with cancer vaccines forecast to grow into an $8B market. Protected by 77 issued and pending patents, Advaxis is extremely well positioned to capitalize on the burgeoning opportunities in the healthcare sector as it advances the development of next-generation treatments for today’s most challenging diseases.
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Re: Advaxis, Inc. (ADXS)

Postby mwest » Mon Dec 17, 2012 8:18 pm

Amazing to consider that cancer vaccines are forecasted to grow into an $8B market
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Re: Advaxis, Inc. (ADXS)

Postby stockseeker30 » Mon Dec 17, 2012 8:53 pm

Show the rapid movement of this disease
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Re: Advaxis, Inc. (ADXS)

Postby armedical » Mon Dec 17, 2012 9:14 pm

This development is huge considering about 50% of sexually active people in the US have been exposed ti HPV?
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Re: Advaxis, Inc. (ADXS)

Postby protostars » Tue Dec 18, 2012 8:11 am

Using bio-engineered bacteria to manipulate the human immune system is already a major step in immunotherapy.
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Re: Advaxis, Inc. (ADXS)

Postby mwest » Tue Dec 18, 2012 10:08 pm

They are making a name for themselves especially amongst the National Cancer Institute, Cancer Research – UK, the Wistar Institute, the University of Pennsylvania, the University of British Columbia, the Karolinska Institutet, and others.
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Re: Advaxis, Inc. (ADXS)

Postby stockseeker30 » Tue Dec 18, 2012 11:24 pm

Big names to have looking your way
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Re: Advaxis, Inc. (ADXS)

Postby protostars » Wed Dec 19, 2012 8:21 am

They're investigating opportunities with cervical cancer, head & neck cancer, canine osteosarcoma, breast cancer, and prostate cancer, a pretty wide net, requiring a number of institutional partners.
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Re: Advaxis, Inc. (ADXS)

Postby armedical » Wed Dec 19, 2012 8:57 am

If you can find a treatment that works well with one type of cancer then that can be modified to treat many other cancers.
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Re: Advaxis, Inc. (ADXS)

Postby mwest » Wed Dec 19, 2012 8:51 pm

WIth so many types of Cancer treatments and reserach is needed badly
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Re: Advaxis, Inc. (ADXS)

Postby stockseeker30 » Wed Dec 19, 2012 9:08 pm

Seems everytime you cure one form another comes along, shows how technology is needed
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Re: Advaxis, Inc. (ADXS)

Postby protostars » Thu Dec 20, 2012 8:13 am

Immunotherapy can be expected to replace much of the cancer treatment regimens currently used.
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Re: Advaxis, Inc. (ADXS)

Postby armedical » Thu Dec 20, 2012 10:29 pm

I think that it is time to update the treatments that are generally used. Chemotherapy has been around since the 1940's.
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Re: Advaxis, Inc. (ADXS)

Postby mwest » Thu Dec 20, 2012 10:32 pm

That is welcoming news especially for patients
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Re: Advaxis, Inc. (ADXS)

Postby stockseeker30 » Thu Dec 20, 2012 11:17 pm

It takes away a lot of the pain associated with treatment and such
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Re: Advaxis, Inc. (ADXS)

Postby protostars » Fri Dec 21, 2012 7:31 am

It's an exciting time to be a researcher in this field.
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Re: Advaxis, Inc. (ADXS)

Postby mwest » Fri Dec 21, 2012 2:03 pm

With funding and technology increasing it is very exciting to see the future so bright for many
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Re: Advaxis, Inc. (ADXS)

Postby stockseeker30 » Fri Dec 21, 2012 2:30 pm

Funding is right time has continued to show nice increases in participation and revenue to help fight these diseases
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Re: Advaxis, Inc. (ADXS)

Postby QualityStocks » Fri Dec 21, 2012 3:11 pm

Advaxis, Inc. (ADXS) Utilizes Unique Immunotherapy Platform Technology

One of the hottest areas in medical technology today is the rapidly growing field of immunotherapy, the manipulation of the body’s own immune system to target and combat cellular based diseases such as cancer. The key to immunotherapy, and the biggest challenge, is to develop a mechanism for interacting with and controlling the body’s immune system that is both safe and effective.

Advaxis, a New Jersey based biotechnology company focused on immunotherapies for cancer and infectious diseases, is utilizing a unique platform technology under exclusive license from the University of Pennsylvania, based upon the work of Yvonne Paterson, Ph.D., Professor of Microbiology. The technology utilizes a live attenuated bacterium, Listeria monocytogenes (Lm), bio-engineered to secrete an antigen/adjuvant fusion (Lm-LLO) protein. Her work has shown that Lm-LLO based immunotherapies stimulate the immune system to induce antigen-specific anti-tumor immune responses involving both innate and adaptive arms of the immune system. In addition, this technology could facilitate the immune response by altering the microenvironment of tumors to make them more susceptible to immune attack.

The company’s initial focus has been on immunotherapies targeting HPV-associated diseases, specifically cervical intraepithelial neoplasia (CIN 2/3), recurrent or refractory cervical cancer, as well as head and neck cancer. In addition, they have developed immunotherapies for prostate cancer and HER2 expressing cancers, such as breast, gastric, bladder, brain, pancreatic, and ovarian cancer.

Advaxis has more than fifteen constructs in various stages of development, with their lead construct, ADXS-HPV, currently in Phase 2 clinical development for recurrent/refractory and advanced cervical cancer, CIN 2/3, and HPV caused head and neck cancers. In April, 2012, ADXS-HPV was recognized as the Best Therapeutic Vaccine (approved or in development) at the 5th Annual Vaccine Industry Excellence (ViE) Awards by the vaccine industry and the journal Expert Reviews of Vaccines.

For additional information, visit www.Advaxis.com
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Re: Advaxis, Inc. (ADXS)

Postby stockseeker30 » Wed Dec 26, 2012 5:21 pm

ADXS deserves alot of attention that they are receiving. I an combined effort from every scientific field we all have a hope for the eradication of diseases such as cancer that have stolen so many love ones young and old.
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