InMed Pharmaceuticals, Inc. (IMLFF)

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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Fri Aug 18, 2017 3:35 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Enters Consulting Agreement with Creative Capital Media

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced its entry into a consulting agreement with Creative Capital Media (“CCM”). Moving forward, CCM, a media and advertising consultancy, will provide communication and awareness services to InMed in North America.
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Wed Aug 23, 2017 4:07 pm

No Eclipse in Sight for InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) as it Moves toward Clinical Trials

- Proprietary biosynthesis process to produce cannabinoids
- Cannabinoid bioinformatics system that identifies optimal R&D pathways
- Lead candidate targeting billion dollar market

Despite the awe-inspiring shadow cast by the moon on August 21, 2017, there’s no eclipse in sight for InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF). The Vancouver, Canada-based company continues its research and development (R&D) into the therapeutic benefits of cannabinoids, an activity that holds the promise of exceedingly rich reward. Peer valuations have skyrocketed, increasing the likelihood that unicorns may soon appear on the cannabis biotech landscape. With a triad of valuable core assets, it won’t be surprising if, sometime in the future, InMed turns out to be one of them.

InMed Pharmaceuticals has more to offer than the typical drug discovery and development company. Its triple play comprises a proprietary technology based on biosynthesis, a bioinformatics system, and a robust drug development pipeline, any one of which may propel this innovative biotech to success. The company has developed a process to manufacture cannabinoids by applying cannabinoid DNA to Escherichia-coli (E. coli) bacteria. The E. coli DNA is then removed, leaving just the cannabinoid DNA, which can then replicate in a process known as biosynthesis. Biosynthesis is widely employed in the pharmaceutical industry and is used, for example, to manufacture the insulin upon which millions of diabetics rely.

InMed’s bioinformatics system, employing proprietary algorithms, identifies the cannabinoids most likely to have beneficial therapeutic effect in serious diseases with high unmet medical needs. The program integrates data from numerous bioinformatics databases, including a database on the structure of currently approved pharmaceutical products and an extensive proprietary database of over 90 individual cannabinoid drugs found in cannabis. This bioinformatics tool has already identified several therapies, including the company’s two lead pipeline candidates, INM-750 and INM-085.

INM-750 is for the treatment of a rare genetic connective tissue disorder called epidermolysis bullosa (EB). EB is an orphan pediatric disease characterized by extremely fragile skin that affects roughly one out of every 20,000 births in the United States. The condition, which currently has no approved treatment or cure, has been called “The Worst Disease You’ve Never Heard Of” by the Dystrophic Epidermolysis Bullosa Research Association of America. INM-750 works by replacing missing keratins in the skin with specially selected cannabinoids in an effort to modulate the painful manifestations of EB. It has potential global market revenues of approximately $1 billion.

INM-085 targets glaucoma, a leading cause of blindness, according to the Glaucoma Research Foundation. The drug reduces the elevated intra-ocular pressure that is often associated with glaucoma and so holds the promise of providing relief to the more than three million Americans who currently have glaucoma.

Both INM-750 and INM-085 are in the pre-clinical phase, and InMed is taking the lead with the former, which it is hoping to advance to phase I clinical trials in 2018. If all goes well, INM-750 is expected to be in phase III by 2020, setting InMed on a trajectory, if peer comparisons are any indication, to a much higher valuation than its current one of under $50 million. Scioderm, for example, was acquired by Amicus two years ago for $847 million. This acquisition was based on the results of a phase II study of its sole clinical asset Zorblisa, which involved only 42 patients. Zorblisa, for the treatment of EB, is currently in phase III.

InMed’s pipeline is in good hands. Its chief scientific officer is Dr. Sazzad Hossein, who brings more than 20 years of academic and industrial experience in new drug discovery and natural health product development to the C-suite. He was, at one time, group leader and senior scientist at Biotechnology Research Institute of National Research Council Canada, the Government of Canada’s prime biotechnology research organization, where he set up a pharmacology laboratory to evaluate the safety and efficacy of new drugs under development in the areas of cancer and cardiovascular and ocular diseases. He is also the author of more than 40 peer-reviewed papers, primarily in the pharmacology, genetics and nutritional sciences.

InMed’s chief medical officer is Dr. Ado Muhammed. Muhammed joined the company from GW Pharmaceuticals, developer of Sativex, where he was associate medical director, distinguishing InMed as the only biopharmaceutical company in North America with a senior GW team member on its executive team.

For more information, visit the company’s website at www.InMedPharma.com
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Fri Sep 01, 2017 3:56 pm

NetworkNewsBreaks – InMed Pharmaceuticals (CSE: IN) (OTCQB: IMLFF) Could Prove to Be a Cannabis Biotech Unicorn

The recent solar eclipse that enthralled the world has come and gone, but no shadow of an eclipse is on the horizon to blot out the progress of InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF). As peer valuations have soared in Canada’s cannabis market, InMed continues its promising R&D efforts into the therapeutic benefits of marijuana, and this Vancouver, Canada-based company may just prove to be one of the unicorns of Canada’s cannabis biotech market. An excerpt from an article further discussing this reads: “InMed Pharmaceuticals has more to offer than the typical drug discovery and development company. Its triple play comprises a proprietary technology based on biosynthesis, a bioinformatics system, and a robust drug development pipeline, any one of which may propel this innovative biotech to success. The company has developed a process to manufacture cannabinoids by applying cannabinoid DNA to Escherichia-coli (E. coli) bacteria. The E. coli DNA is then removed, leaving just the cannabinoid DNA, which can then replicate in a process known as biosynthesis. Biosynthesis is widely employed in the pharmaceutical industry and is used, for example, to manufacture the insulin upon which millions of diabetics rely.”
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Sep 12, 2017 3:42 pm

Cannabis Biotechs Taking Leading Stance in Global Marijuana Market

With leading recent estimates clocking the 2016 North American legal cannabis market between $6.7 and $7.2 billion, the only thing more impressive about the industry is the growth projections. Research estimates a whopping compound annual sales growth rate of 25 percent through 2021. This stupendous growth, driven by more and more states adopting medical and even recreational legislation, has combined with the fact that the FDA has not yet approved any drug product containing or derived from botanical marijuana to create a perfect storm for cannabis biotechs like Vancouver-based InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) (IMLFF Profile) and GW Pharmaceuticals (NASDAQ: GWPH). Medical marijuana has among the highest values in the broader marijuana space, and as with any burgeoning industry, savvy investors are looking for evidence of the market’s core value. A look at the operations of Canopy Growth Corp. (TSX: WEED) (OTC: TWMJF), Aphria, Inc. (TSX: APH) (OTC: APHQF) and Aurora Cannabis (TSX: ACB) (OTC: ACBFF) provides insight into various niches within the marijuana industry to help identify why cannabis biotechs are the value sweet spot.

Despite its incredible potential, the success of medicinal marijuana’s success in the U.S. is crimped by cultivation capabilities. Due to the notoriously stringent regulatory environment in the U.S., much of the research and even plant cultivation has historically been done outside the country, with Israel rapidly evolving into the premier cannabis research and development location on earth, as the nation’s scientists and producers chase what will potentially be a $50 billion global market by 2025. Second only to Israel in this regard is Canada, where top growers are benefitting from Access to Cannabis for Medical Purposes Regulations (ACMPR) that allow commercially licensed production. This limited participation market has been very good for Canadian growers that have achieved licensing, with only 58 participants to date. However, the real value of the industry lies in the biotechs using cannabinoids extracted from the cannabis plant to develop their drug candidates and potentially change the entire future landscape of the medical marijuana industry.

Evidence of the value of cannabis biotechs is revealed in the Bloomberg Intelligence Global Cannabis Competitive Peers Index (http://nnw.fm/8bZ6k), which shows the collective market cap of cannabis bio-pharma at $5.6 billion, outpacing the valuation of cannabis producers at $3.4 billion. While current cannabis drug development is handicapped by the expensive industry standard “grow-harvest-extract-purify” process, GW Pharmaceuticals’ ability to jump from $8 a share to more than $120 a share following news of its new drug, is a prime example of the types of gains cannabis biotechs can achieve, and what makes them dominate the Bloomberg index.

As noted in the Bloomberg piece, InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) could become a major breakout player, differentiating itself from leading developers like GW Pharmaceuticals with biosynthetic offerings and two key drug indications. This is a key advantage for InMed, which has a market cap of $34 million, but to better understand this advantage and valuation potential, it pays to examine the underlying market dynamics in greater detail.

There are more than 90 cannabinoids that have been isolated from cannabis, each affecting the body’s cannabinoid receptors and responsible for unique pharmacological effects. Because these cannabinoids are so small in size, isolating these compounds in usable volume requires the cultivation of large quantities of cannabis, currently some cannabinoid compounds are found in such small volumes in the plant they are not commercially viable for study in drug development.

InMed Pharmaceuticals, however, enjoys the unique benefit of developing a cannabinoid biosynthesis process to provide access to the entire suite of all 90 plus naturally-occurring cannabinoids (not just THC or cannabidiol). Rather than having to rely on outside cultivators in Israel or Canada, InMed uses its proprietary, high-yield biosynthesis process capable of manufacturing pharmaceutical grade, bio-identical cannabinoids in the lab.

Diseases such as the primary targets of InMed’s current drug development pipeline, like glaucoma, which the company is targeting the root cause of via INM-085. Designed as a topical formulation which facilitates absorption by the eye, the proprietary, polymer-based INM-085 is a novel, multi-target, multi-mechanism package of cannabinoids focused on relieving the intra-ocular pressure build up which leads to optic nerve damage in glaucoma patients. INM-085 simultaneously provides key neuroprotectant properties that help optic nerve tissues and retinal ganglion cells survive adverse conditions. Glaucoma therapeutics was a $5.7 billion market only two years ago, with projections of a 3.4 percent CAGR through 2024, and the broader ophthalmic drug market is on-track to top $30 billion by 2020.

Another disease currently targeted by InMed’s development pipeline is epidermolysis bullosa (EB), a connective tissue disorder characterized by the absence of certain proteins in the skin, and currently classed as an orphan disease for which there remains significant unmet medical need. INM-750 is just as novel as INM-085, utilizing a broad-spectrum approach to modulate levels of the key protein responsible for protecting epithelial (skin) cells from damage and stress, known as keratin. In addition, INM-750 was specifically designed to alleviate associated symptoms like inflammation, itching, pain, while promoting wound healing, and skin cell regeneration. INM-750 is on target for clinical trials as early as next year and the global market for EB and glaucoma combined is easily over $6 billion.

These target markets are just the tip of the iceberg, in terms of market opportunity. With a valuation of $3.4 billion, GW Pharmaceuticals (NASDAQ: GWPH) may be the frontrunner in the search for cannabis-based therapeutics, but small biotechs like InMed (CSE: IN.c) (OTC: IMLFF) are demonstrating the vast potential of cannabis therapies and their value in the broader medical industry.

GW Pharmaceuticals has been in the cannabinoid research game since the late 90s and has become one of the most talked about developers of plant-derived cannabinoid therapeutics today. Widely known for bringing the world’s first plant-derived cannabinoid prescription drug (Sativex) to market for spasticity in multiple sclerosis patients, GW Pharmaceuticals markets the drug in 29 countries outside the U.S. and is currently in phase 3 pivotal trials for Epidolex, which has been granted both Orphan Drug Designation and Fast Track Designation by the FDA. The company also famously decided to keep its entire plant production footprint in the UK last year, despite driving hard toward sizeable U.S. markets with Epidolex, and migrating its shares from London markets exclusively to the Nasdaq exchange.

The success and valuation of Canada’s medical marijuana growers, cultivators and producers sheds light on increasing global demand and necessity for high-volume, high-quality plants for medicinal purposes.

Canopy Growth’s (TSX: WEED) (OTC: TWMJF) is among leaders on the production side of the marijuana industry, with a market cap of $1.4 billion (CAD) as of September 11. The company’s Bedrocan brand is billed as the epitome of medical-grade cannabis due to decades of selection and refinement. Enabling the company to produce consistent, standardized whole bud cannabis strains, as well as see those strains become used extensively by clinical researchers across seven European countries. With a production footprint of over half a million square feet, Canopy Growth is one of the biggest growers in Canada. The company recently moved to further solidify its expansion in New Brunswick with the acquisition of ACMPR applicant Spot Therapeutics, which when licensed will produce roughly 8,800 pounds a year, and when fully expanded will provide around 100,000 square feet of production space. The company also expanded its Smiths Falls and our Bowmanville South footprints last quarter by 33% and 200% respectively.

Currently valued at $831.5 million (CAD), Aphria, Inc. (TSX: APH) (OTC: APHQF) is one of the lowest cost producers in Canada and was the first publicly licensed producer to go cash flow positive from operations. The recent announcement of a $25 million investment in order to effectively gain a strategic U.S. presence via one of only seven licensees in the entire state of Florida is a big move for the company, which will operate in the U.S. under the Aphria USA brand. A big move, but with nearly 21 million people in Florida and many of them elderly, this market could be a real goldmine for Aphria, as it represents some 14 percent of the total U.S. medical cannabis market, valued at over $1.1 billion.

Aurora Cannabis, Inc. (TSX: ACB) (OTC: ACBFF) surpassed 19,000 active registered patients in the company’s first 20 months after initial product sales and has over 55,000 square feet in Alberta at its state-of-the-art production facility. Aurora is also currently in the process of tacking on an additional 840,000 square feet across two other sites in Canada. The company owns a 19.9% stake in the first Australian company licensed to cultivate and conduct research on medical cannabis, Cann Group Limited. As well as owning a leading Germany-based wholesale importer, exporter, and distributor of medical cannabis, known as Pedanios. Pedanios even recently passed the first stage of the tender application process in Germany to become a licensed medical cannabis producer, which will further expand the company’s presence in the EU. Aurora’s market cap is $969.0 million (CAD)

As investors find their footing in the global marijuana industry, the potential for cannabis biotechs is reaching unprecedented proportions thanks to the innovations and drug development capabilities of companies like InMed and behemoths like GW Pharmaceuticals.

For more on IMLFF please visit: InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF)
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Sep 12, 2017 4:20 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Files Provisional Patent Covering Proprietary Biosynthesis Program

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced its filing of a provisional patent application pertaining to the company’s biosynthesis program for the manufacture of cannabinoids that are identical to those found in nature. Per the news release, this patent application, once converted into an international Patent Cooperation Treaty (PCT) application and pursued in key jurisdictions around the world, will offer significant commercial protections for InMed’s promising E. coli-based expression system, which enables the manufacture of any of the 90+ cannabinoid compounds found in the cannabis plant. “This novel approach to the biosynthesis of cannabinoids is a game-changer for drug development,” Dr. Vikramaditya Yadav, Assistant Professor of Chemical and Biological Engineering at the University of British Columbia, stated in the news release. “The importance of producing cannabinoids that are identical to the naturally occurring compounds cannot be overstated. Many drug development efforts with synthetic derivatives have failed.”
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Wed Sep 13, 2017 4:05 pm

Biosynthesis Technology Could Transform Cannabinoid Production

NetworkNewsWire Editorial Coverage: The upward trajectory of the cannabis industry has garnered comparisons to the Internet boom of the early 2000s, as North American sales are on pace to record a compound annual growth rate of 25 percent through 2021, according to Arcview Market Research (1). These comparisons are certainly attention-grabbing, but the full potential of the evolving marijuana market could be even larger. InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) (IMLFF Profile), a Vancouver-based biopharmaceutical company, has developed a robust, high-yield biosynthesis process capable of enabling the manufacture of all 90+ naturally-occurring cannabinoids found in the cannabis plant. This could be a game changing development for companies operating within the burgeoning sector, including Axim Biotechnologies, Inc. (OTCQB: AXIM), GW Pharmaceuticals (NASDAQ: GWPH), Zynerba Pharmaceuticals, Inc. (NASDAQ: ZYNE) and pharmaceutical heavyweight Eli Lilly and Company (NYSE: LLY).

Perhaps the clearest way to demonstrate the potential of an effective cannabinoid biosynthesis platform is to study a more established product – bio-synthetic insulin. Healthline estimates that 29.1 million people in the United States have diabetes, with diagnosed cases costing the country an estimated $245 billion in 2012. Although the chronic disease accounted for nearly 1.6 million deaths in 2015, according to data from the World Health Organization, a scientific breakthrough in 1921 greatly improved the survivability of diabetes. As documented by a contributor to The Seed Investor, it was then that a team of Canadian researchers discovered a way to process pig pancreases into a human insulin replacement.

While this discovery certainly improved the outlook for diabetes sufferers, it was just the first step toward the insulin market as it exists today. Originally, pharmaceutical insulin was produced directly from the organs of pigs, with it taking roughly “5,000 pig pancreases to produce just eight ounces of insulin.” Put simply, this process was expensive and time-consuming, and, while producer Eli Lilly and Company certainly capitalized on the breakthrough, a discovery in the 1970s once again changed the game. A small biotechnology firm called Genentech used recombinant DNA techniques to successfully produce a bio-synthetic “human” insulin, making it the first human protein to be manufactured through biotechnology. In addition to being significantly cheaper to produce than animal-derived alternatives, this synthetic insulin was shown to cause less allergic reactions in patients. Within a few years, biosynthetic insulin replaced the vast majority of animal-based alternatives, and the companies at the heart of the innovation have reaped the rewards. Genentech was acquired by Roche Holdings for $48 billion in 2009, while a 2014 report from Transparency Market Research predicted that the global insulin market will reach $32.24 billion by 2019.

Parallels between the insulin market of the 1960s and today’s pharmaceutical cannabinoid industry are too clear to be ignored. Cannabis biotech companies are currently producing millions of plants each year in order to extract the cannabinoids that are central to their products and development candidates. However, maintaining the controlled conditions required to produce consistent plants is both costly and time-consuming, and competitive market conditions in drug development cost will see these pressures from growing and manufacturing expenses. Agricultural and Capital Expense cost are high, from Land, facility costs with high-efficiency lighting systems and sophisticated greenhouse production facilities, investors are pouring millions of dollars into pot production. The cost for the cannabinoids, the active pharmaceutical ingredients (API’s) needed in cannabis drug development are staggeringly high. InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF), with its innovative biosynthesis technology utilizing modified E-coli bacteria, could be approaching the introduction of a cheaper and better alternative for providing the API’s in the massive industry’s cannabinoid-focused segment following its filing of a provisional patent application pertaining to the technology earlier this week.

Potential benefits of biosynthesis of cannabinoids are wide-ranging, as InMed Pharmaceuticals notes in its corporate presentation. The cost savings versus traditional growing and extraction methods are certainly noteworthy (and they echo the benefits of bio-synthetic insulin nicely), but monetary benefits are just the tip of the iceberg. Because the cannabinoids produced using InMed’s proprietary manufacturing techniques are bioequivalent to the naturally-occurring compounds, biosynthesis could enable enhanced quality control and purification. Importantly, the technology could be key in unlocking the minor cannabinoids that are currently economically unfeasible to produce and comprehensively study. The company estimates that its cannabinoid biosynthesis process, a method that’s been likened to a “pharmaceutical copy machine” for its ability to produce bioequivalent compounds.

“This novel approach to the biosynthesis of cannabinoids is a game-changer for drug development. The importance of producing cannabinoids that are identical to the naturally occurring compounds cannot be overstated. Many drug development efforts with synthetic derivatives have failed,” Dr. Vikramaditya Yadav, Assistant Professor of Chemical and Biological Engineering at University of British Columbia, a co-inventor of the biosynthesis technology, stated in a recent news release (http://nnw.fm/Z30dH). “In our extensive experimentation, the E. coli system is more robust and more efficient for the manufacturing of cannabinoids as compared to other microbial platforms.”

Links between Eli Lilly’s early ventures in the synthetic insulin market and InMed’s current forays into cannabinoid biosynthesis were reaffirmed by InMed’s January 2017 appointment of Martin Bott to its board of directors. Following Bott’s appointment, market analysis firm CFN Media called the move “a strong vote of confidence for [InMed’s] future.” Bott has worked at Eli Lilly for nearly 30 years prior to his appointment to the InMed board, overseeing the drug giant’s investment of more than $1 billion into biosynthesis research. As InMed President and CEO Eric A. Adams noted in a news release following the addition, “Martin Bott has established a significant leadership position in financial and business expertise with one of the world’s leading pharmaceutical companies. His depth of knowledge in navigating the complexities in healthcare finance and operations on a global level will be invaluable to InMed.”

InMed’s intellectual property portfolio also includes a promising drug development pipeline targeting unmet medical conditions using non-THC cannabinoids. The company’s lead candidate, INM-750, is currently being evaluated as a topical treatment for epidermolysis bullosa, an orphan pediatric disease, characterized by extremely fragile skin, that has no currently approved therapies. InMed estimates the market potential of INM-750 at $1 billion, with phase I clinical trials scheduled to begin in 2018. The company is also developing INM-085 for the treatment of glaucoma, a serious eye disease with a global market valued in excess of $5 billion. INM-085 is currently being evaluated in pre-clinical studies. These drug candidates further strengthen InMed’s position within the burgeoning cannabis sector, providing an additional application for its groundbreaking biosynthesis platform.

The activity of other cannabis industry players highlights the huge market potential of InMed’s novel approach to cannabinoid biosynthesis. Axim Biotechnologies, Inc. (AXIM) is currently developing a diversified and robust clinical pipeline of cannabinoid-based products. Its most advanced program is its phase II clinical trial of its MedChewRx™ chewing gum for the treatment of irritable bowel syndrome. Axim anticipates completing this trial in the near-term and advancing toward a pivotal phase III clinical trial by early next year.

Coinciding with this advancement, Axim has made numerous moves in recent months to secure the needed supply of cannabinoids required to evaluate the efficacy of its development pipeline. In addition to importing pharmaceutical-grade hemp oil from Italy, Spain and Denmark, Axim recently purchased land in the Netherlands in order to facilitate the construction of a state-of-the-art manufacturing facility. Per the company’s website, “Axim is in the process of developing a unique extraction and freeze-drying technology for production of molecularly/genetically controlled—therefore extremely pure—pharma-grade cannabinoids extracted from industrial hemp.” As noted in a November 2016 news release, this platform will focus primarily on the extraction of THC, the most commonly known cannabinoid derived from the cannabis plant.

GW Pharmaceuticals (GWPH) is well-known within the cannabis industry as the company behind the world’s first prescription drug derived from the cannabis plant, Sativex®, which is approved for the treatment of spasticity due to multiple sclerosis in 28 countries worldwide. The company’s lead cannabinoid product candidate is Epidiolex®, a liquid formulation of pure plant-derived cannabidiol being developed for the treatment of a number of rare childhood-onset epilepsy disorders. As noted on its website, GW is currently in a “unique position to develop and manufacture plant-derived cannabinoid formulations worldwide at sufficient quality, uniformity and scale,” but some analysts have expressed doubt regarding the sustainability of this model. In an article published last year by Seeking Alpha, a contributor noted the recent fall in CBD prices concurrent with increasing supply. “The popularity and history of cannabis growing, combined with the large amounts of arable land, cheap pharmaceutical manufacturing, and cheap labor in India should scare anyone invested in hemp farming,” the article states. “The price-points we are seeing now don’t seem sustainable.” Synthetic cannabinoids, as produced through InMed’s proprietary biosynthesis platform, could provide a long-term solution to this issue.

The recent activity of Zynerba Pharmaceuticals, Inc. (ZYNE) reiterates the potential marketability of InMed’s platform. Zynerba’s shares plummeted to 52-week lows last month after the company announced disappointing top-line results from its phase II study of ZYN002, marketed as the first and only synthetic CBD formulated as a patent-protected permeation-enhanced gel for transdermal delivery through the skin and into the circulatory system. As noted on its website, Zynerba’s product candidates are “synthetically manufactured per FDA/CGMP regulations” in an effort to “provide consistent potency and eliminate impurities in the product.” Similar to InMed’s biosynthesis platform, Zynerba’s manufacturing techniques offer several advantages over botanically-derived cannabinoids, dodging “the natural resources and security measures required to grow Cannabis, as well as the strict batch controls required by regulatory agencies in pharmaceutical manufacturing.”

A report published by the National Institutes of Health affirms that cannabinoids have a very high therapeutic index with low toxicity, and the market is currently filled with companies looking to translate these benefits into returns for shareholders. Since the 1980s, when Eli Lilly and Company (LLY) developed a synthetic THC product called Nabilone to treat nausea associated with chemotherapy, demand for biosynthetically-produced cannabinoids that are bioequivalent to those that occur naturally within the cannabis plant has been on the rise. InMed Pharmaceuticals could be approaching this breakthrough with its robust, high-yield biosynthesis process, presenting an enticing opportunity for investors looking to capitalize on rising demand for cannabinoid-based pharmaceuticals.

Editorial Sources:
1) Arcview Research http://nnw.fm/OHz8c

For more information on InMed Pharmaceuticals, Inc. please visit: InMed Pharmaceuticals
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Thu Sep 14, 2017 5:06 pm

InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Builds Moat around Proprietary Biosynthesis Technology

- Proprietary biosynthesis process to produce cannabinoids
- Provisional patent application filed
- Cost-effective methodology to produce trace cannabinoids

If you have any doubt that InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) is on the right track as it moves to protect its biosynthesis technology for cannabinoids, then a word from a famed figure may make you change your mind. Known worldwide for his investing prowess, Warren Buffett has said, “I don’t want a business that’s easy for competitors. I want a business with a moat around it with a very valuable castle in the middle” (http://nnw.fm/ILqd2). Naturally, the Sage of Omaha was referring to an economic moat and not its tangible water-filled counterpart. One obvious way of constructing such an economic moat would be by registering a patent, which is exactly what InMed is planning to do. The company, which specializes in the research and development (R&D) of novel, cannabinoid-based drug therapies, has announced the filing of a provisional patent application for its proprietary biosynthesis process for the manufacture of cannabinoids that are identical to those found in nature (http://nnw.fm/lGxK8).

This filing is the first step in setting up defenses. Under U.S. patent law, a provisional patent application filed with the United States Patent and Trademark Office (USPTO) allows the filer to get a filing date and book a place in the queue. But, just as importantly, it affords protection for up to 12 months without filing a complete patent application. The provisional application may later be converted into a non-provisional one or be replaced by a regular patent application. The process in Canada, although not the same, is very similar.

To obtain protection outside North America, the Patent Cooperation Treaty (PCT) offers one streamlined route. The PCT procedure facilitates a patent application in all contracting states that are signatories with one filing, obviously a boon, since 145 sovereign states are members of the PCT. The PCT process allows the filing of an “international patent application,” which acts as an initial application for a patent in any member country. However, an “international patent application” never matures into an “international patent”. No such animal exists. A PCT filing simply reduces the burden of individual filings to contracting states and acts as a patent application to the contracting state in which the patent is meant to go into effect. Patents are issued by sovereign states and are always limited to national boundaries.

InMed’s provisional patent application will protect the biosynthesis process it has developed for the production of cannabinoids. In itself, biosynthetic production of chemicals is nothing new, but it really took off in 1978 after Genentech succeeded in modifying Escherichia-coli (E-coli) bacteria to produce synthetic insulin, a breakthrough credited with saving thousands of lives. Insulin is required by diabetics, whose bodies either do not produce the hormone or handle it inefficiently, in order to absorb glucose. In its absence, blood sugar increases to levels that may damage internal organs. Before biosynthesis, insulin was produced from the pancreas of pigs and cows in a costly, rather inhumane process.

InMed’s biosynthesis technology involves a process that can be applied to manufacture all the naturally occurring cannabinoids, through which the DNA of the cannabinoid to be produced is applied to Escherichia-coli (E-coli) bacteria. The E-coli DNA is then removed, leaving just the cannabinoid DNA, which can then replicate and multiply. This process combines the inherent safety and known efficacy of the natural drug structures with the convenience, control and quality of a laboratory-based manufacturing process.

InMed’s biosynthesis methodology will likely be used to produce the less naturally occurring phytocannabinoids such as delta-8 tetrahydrocannabinol (Δ8 THC), cannabidivarin (CBDv), and tetrahydrocannabivarin (THCv), although, for the present, the company is not saying. Regardless of which cannabinoid castles InMed decides to build, they will all be protected by a sturdy economic moat.

For more information, visit the company’s website at www.InMedPharma.com
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Sep 19, 2017 4:17 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Retains Consulting Services of Ben Paterson

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced that it has retained the consulting services of Ben Paterson, P.E., to assist in defining the pathway for scale-up, purification and manufacturing strategies related to the company’s cannabinoid biosynthesis program. Paterson brings nearly four decades of experience in developing pharmaceutical manufacturing and purification processes to the InMed team, having previously served as a senior engineering advisor with Pharmaceutical giant Eli Lilly and Company for nearly four decades. “Mr. Paterson brings significant experience in all facets of biosynthesis manufacturing and facility design,” Eric A. Adams, president and CEO of InMed, stated in the news release. “His expertise directing complex capital projects, overseeing facilities and equipment, and interfacing with various stakeholders will be a significant asset to InMed.”
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Thu Sep 21, 2017 6:33 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Announces Inclusion in CSE25 Index

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced that it has been included in the CSE25 Index after qualifying as one of the 25 largest companies in the CSE Composite Index. Per the update, the CSE25 Index is a subgroup of the CSE Composite Index, which was launched in 2015 and currently includes nearly half of the exchange’s listed companies and over 75 percent of the trading activity on the Canadian Securities Exchange. The CSE25 Index includes the top 25 securities contained within the CSE Composite Index based on market capitalization. According to the exchange, CSE25 companies account for more than 50 percent of the weighting of the larger CSE Composite Index, meaning that the 25 included stocks typically attract “considerable trading volume.”
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Sep 26, 2017 1:06 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Provides Update on Advancements of Proprietary Biosynthesis Technology

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning provided an update to its investors on the significant advancements in the development of its proprietary technology for the microbial biosynthesis of cannabinoids. InMed has successfully demonstrated that it can selectively produce all four “gateway” cannabinoids using genetically engineered microorganisms. These molecules can be further functionalized to produce any of the 90+ cannabinoids that occur naturally in the cannabis plant. “Successful scale-up and commercialization of the biosynthesis process for cannabinoid production is a top priority for InMed,” Eric A. Adams, president and CEO of InMed, stated in the news release. “We are dedicating substantial resources to this project and have retained key individuals as we transition into the advanced pilot and to the commercialization phases of development. The breadth and depth of our patents, currently either submitted or being prepared for submission, will provide significant protection to the entire process.”
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Sep 26, 2017 4:20 pm

Medical Cannabis Companies Leverage Biosynthesis to Boost Drug Development

NetworkNewsWire Editorial Coverage: Scientists have discovered more than 90 known cannabinoid compounds that may have potential to fight disease and have beneficial health effects. For biotech companies looking to harness these compounds for drug development, the challenge is two-pronged: the time consuming, expensive process of sourcing cannabinoids naturally and removing impurities, or safely and efficiently attempting chemical synthesis of compounds identical to those found in nature, a problem driven by the requirements of the FDA. InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) (IMLFF Profile) has found a solution to these problems by utilizing the DNA of naturally occurring cannabinoids to produce, in a laboratory setting, compounds identical to those found in nature. The future of cannabinoid-based medicine hinges on such innovations which is: the ability to produce cannabinoids identical to those found in nature in a safe, consistent and economical fashion to advance cannabis-based drug development. Others active in this field are GW Pharmaceuticals PLC (NASDAQ: GWPH), Zynerba Pharmaceuticals Inc. (NASDAQ: ZYNE), 22nd Century Group Inc (NYSEMKT: XXII) and Axim Biotechnologies Inc. (OTCQB: AXIM).

Alone or in combination, cannabinoids can fight diseases such as diabetes, Alzheimer’s, depression, and even cancer. Chemical synthesis is one method tried by pharmaceutical companies exploring the health benefits of cannabinoids for their own product pipeline. However, it is difficult to synthesize compounds identical to their natural counterparts, as the slightest structural variations can affect the potential efficacy and safety of the finished product. Companies utilizing extraction methods for the cannabis plant find that planting, growing, harvesting, and extracting cannabinoids for medicinal use are time consuming, while the water, electricity and manpower needed adds to the expense. In addition, fertilizers and pesticides can be hard to remove, and crop fluctuations can affect yield. Producers are also often strained by the management of time, effort, and expense, not to mention chemical waste.

The challenges of both chemical synthesis and botanical extraction are a thing of the past for InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF), which has discovered a way to manufacture cannabinoid compounds in quantities and purities (above 95%) suitable for pharmaceutical use, largely eliminating previous concerns.

InMed’s solutions is a biosynthesis process, utilizing the bacterium E. coli, that starts with cannabinoid DNA so compounds identical to those found in nature can be created in a controlled laboratory. Each cannabinoid can be manufactured individually, to strict purity standards, and without the need to separate individual compounds. Applicable to any of the 90+ cannabinoids, the process involves less time and cost, while a controlled environment affords a high level of quality control every step of the way. In fact, biosynthesis is part of the company’s key intellectual property.

InMed recently filed a provisional patent, which will be converted to an international Patent Cooperation Treaty (PCT) application in the coming months. Upon approval, this coverage will provide InMed’s E. coli-based expression system commercial protection. A series of patent applications is expected to follow, boosting the company’s cannabinoid biosynthesis program, one of its three core assets that also include a drug development program (with pipeline drugs for Epidermolysis bullosa, glaucoma, and pain), and a bioinformatics assessment tool to target specific compounds for diseases.

“This novel approach to the biosynthesis of cannabinoids is a game-changer for drug development. The importance of producing cannabinoids that are identical to the naturally occurring compounds cannot be overstated. Many drug development efforts with synthetic derivatives have failed,” Dr. Vikramaditya Yadav, Assistant Professor of Chemical and Biological Engineering at University of British Columbia, a co-inventor of the biosynthesis technology, stated in a news release announcing the provisional patent filing. “In our extensive experimentation, the E. coli system is more robust and more efficient for the manufacturing of cannabinoids as compared to other microbial platforms.”

One could argue that InMed’s biotech innovation is the next big thing since Canadian researchers discovered how to use insulin sourced from animal pancreases to replace human insulin in 1921 (http://nnw.fm/O5fHz).

Harvesting insulin from animal organs became big business. Indianapolis, Indiana, based Eli Lilly and Company was the leader in this arena for nearly 60 years. That was until the discovery of biosynthetic insulin by Genentech, utilizing an E. coli-based system similar to InMed’s. The two businesses ended up in a partnership, growing Eli Lilly into a $73 billion pharmaceutical giant.

Aside from its biosynthesis program, a considerable portion of InMed’s potential centers on the fact that it has the world’s leading experts to advance and commercialize the technology it has perfected. The recent addition of Ben Paterson, P.E., as a consultant is case-in-point. Paterson previously served as a senior engineering advisor with Eli Lilly and Company, where he spent 24 of his 37 years in their biosynthesis division. His expertise includes defining laboratory process and scaling them to support pilot and commercial scale development, and integrating biochemistry, equipment, and process control. Paterson is also experienced at designing, constructing, operating, optimizing, and troubleshooting large and small molecule drug facilities.

There are other biotech companies working to commercialize pharmaceutical-grade medical marijuana that passes FDA requirements. UK-based GW Pharmaceuticals PLC (NASDAQ: GWPH) is one of them. The company’s lead candidate is a pure cannabidiol liquid formulation, Epidiolex® (http://nnw.fm/6gEdh), to treat childhood-onset epilepsy. A 2016 report noted it had the capacity to manufacture enough drug to treat 40,000 patients annually (http://nnw.fm/Qvu53). Savitex®, an oral mucosal spray, has been commercialized to treat individuals with multiple sclerosis, while the biotech firm has worked to explore cannabinoid molecules for treating glioma and schizophrenia.

Further demonstrating the marketability of InMed’s platform is Zynerba Pharmaceuticals, Inc. (ZYNE), which last month reported disappointing top-line results from its phase II study of ZYN002, positioned as the first and only synthetic CBD formulated as a patent-protected permeation-enhanced gel for transdermal delivery through the skin and into the circulatory system. Per the company’s website, Zynerba’s product candidates are “synthetically manufactured per FDA/CGMP regulations” to “provide consistent potency and eliminate impurities in the product.” Like InMed’s biosynthesis platform, Zynerba’s manufacturing techniques hold several advantages over botanically extracted cannabinoids, sidestepping “the natural resources and security measures required to grow cannabis, as well as the strict batch controls required by regulatory agencies in pharmaceutical manufacturing.”

The biotech innovations of 22nd Century Group Inc (NYSEMKT: XXII) have addressed U.S. federal restrictions on THC content for hemp crops. Under U.S. law, crops having more than 0.3% THC must be destroyed, as stated on the company’s website (http://nnw.fm/z2Acc). It also reveals XXII has developed zero-THC industrial hemp plants that have optimized levels of CBD, CBG, CBC, and other medically significant cannabinoids. Working with university research partners, the company is working to adapt different plants to various climates, and has exclusive rights to commercialize these plants in the U.S. It has also developed a means to genetically engineer tobacco plants to regulate the level of nicotine, among other nicotinic alkaloids, to develop smoking cessation and reduced-risk tobacco products.

Axim Biotechnologies (OTCQB: AXIM) has employed its cannabinoid compounds to produce MedChewRx™, a chewing gum to treat irritable bowel syndrome. MedChewRx is currently the most advanced program in the company’s clinical pipeline, now in phase II trials. Phase II trials are expected to begin by early 2018. Also in Axim’s clinical development pipeline (http://nnw.fm/xTs6H) are chewing gums for pain/spasticity in multiple sclerosis, nausea/vomiting/loss of appetite, and opioid addiction/dependence. A capsule for Crohn’s disease is also in development.

At the core of these company’s cannabis exploration is that cannabinoids have been found to have high therapeutic value while being low in toxicity, tapping into the human body’s natural endocannabinoid system. The results of more than 23,000 studies have noted positive benefits, according to Medical Marijuana, Inc. (http://nnw.fm/8TJb2), and fewer barriers to drug development promise an environment favorable for growth in the world’s medicinal cannabis markets. InMed is using novel techniques to develop new drugs for common diseases, by expediting the production of the more than 90 known cannabinoids. These firms are not just looking to benefit shareholders, but also patients from all walks of life.

For more information on InMed Pharmaceuticals, visit InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF)
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Wed Sep 27, 2017 5:06 pm

InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Targets Specific Diseases with its Proprietary Biotechnologies

- Provisional patent application protects unique process yielding pharmaceutical grade, bio-identical cannabinoids
- Proprietary research allows production of synthetic cannabinoids for therapeutic use with certain diseases
- Early stage clinical trials are expected to begin in 2018 for a drug targeting a rare children’s skin disorder

Imagine having a painful disease that causes your skin to blister at the slightest minor injury. Even just scratching an itch or accidentally rubbing against a rough object could cause peeling blisters and acute suffering. Epidermolysis bullosa, a genetic connective tissue disorder that affects roughly one out of every 20,000 births in the United States, currently has no approved treatments, according to the Dystrophic Epidermolysis Bullosa Research Association of America. Researchers at InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF), however, hope to treat this unmet medical need with a topical drug called INM-750 that includes multiple biosynthesized cannabinoids as its active ingredients.

Vancouver, Canada-based InMed Pharmaceuticals is a preclinical biotech company that specializes in developing novel drug therapies by manufacturing cannabinoids with the potential to have a therapeutic effect on specific diseases. The company’s biosynthesis platform works by inserting the plant’s DNA into E. coli bacteria that has the internal ability to manufacture specific cannabinoid compounds.

Couple this approach with a proprietary bioinformatics data assessment tool created by InMed Pharmaceuticals, and the possibilities are endless. In its corporate presentation, the company details the potential benefits of biosynthesis of cannabinoids as wide-ranging, noting that the procedure could enable enhanced quality control and purification while unlocking the minor cannabinoids that are currently too difficult and expensive to produce and study (http://nnw.fm/d7MHp).

Glaucoma, one of the world’s leading causes of blindness, is another life-changing disease that InMed’s proprietary research is zeroing in on. InMed’s INM-085 biosynthesized, topical glaucoma treatment will be the first of its kind – utilizing numerous cannabinoids for optimal efficacy as it treats the affected eye’s cells and optic nerve tissues. The company projects the potential revenue for these two drugs alone at $6 billion a year (http://nnw.fm/L32rz).

But there are other, equally devastating diseases that InMed Pharmaceutical researchers propose targeting in their quest to biosynthesize therapeutic drugs from cannabis and other botanical sources. Rheumatoid arthritis, epilepsy, asthma and diabetes are some of the more well-known names. The benefits of using InMed’s proprietary biosynthesis procedure to manufacture any of the 90-plus identified cannabinoids in marijuana reads like a wish list for investors:

There are significant cost savings versus the traditional method of growing thousands of plants and then extracting cannabinoids
Quality control, which includes enhanced production and purification, means a superior, standardized product
InMed’s comprehensive database uses a bioinformatics platform to select specific cannabinoid combinations that may help treat targeted diseases
Preclinical formulation of therapy drugs this year will lead to expected clinical trials in 2018
Leading research estimates set the 2016 legal cannabis market in North America anywhere from $6.7 billion to $7.2 billion. Growth projections are also “off the charts,” as a stunning compound annual sales growth rate of 25 percent is expected through 2021, and a $50 billion global market is considered possible by 2025 (http://nnw.fm/l0EKZ).

Looking ahead, InMed Pharmaceuticals President and CEO Eric A. Adams said he believes the company’s technology will have a huge impact on the booming cannabis industry.

“When I saw the technology that InMed has, I knew right away that it was going to be something big,” Adams said in a recent interview published in MERRY JANE, an online resource for news, culture and video covering cannabis. “The science behind the company is a real game changer (http://nnw.fm/O3ptU).”

In a move to strengthen the company’s core, InMed has also retained the consulting services of Ben Paterson, P.E., who will assist in defining the pathway for the scale-up, purification and manufacturing strategies for the company’s cannabinoid biosynthesis program. Patterson is a principal consultant at PatersonChemE Consulting, LLC.

Paterson has nearly four decades of experience in developing pharmaceutical manufacturing and purification processes. He previously spent 37 years with Eli Lilly and Company as a senior engineering advisor, including 24 years in the biosynthesis division. His expertise includes first defining processes in the lab, then scaling up to pilot and commercial scale.

“Mr. Paterson brings significant experience in all facets of biosynthesis manufacturing and facility design,” Adams said in a news release announcing Paterson’s appointment (http://nnw.fm/0jdLo). “His expertise directing complex capital projects, overseeing facilities and equipment, and interfacing with various stakeholders will be a significant asset to InMed.”

For more information, visit the company’s website at www.InMedPharma.com
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Thu Sep 28, 2017 3:56 pm

Cannabinoid Biosynthesis Poised as Potential Game-Changer in Drug Development

NetworkNewsWire Editorial Coverage: As the marijuana market continues its widespread growth, researchers remain merely at the threshold of exploring the manifold potential medical applications of cannabis. At present, more than 90 individual cannabinoid compounds have been discovered within the cannabis plant—each one potentially possessing crucial disease-fighting properties either on its own or combined with other compounds. Historically, however, it has been incredibly difficult to extract most of these compounds from the marijuana plant in adequate quantities and purities to be tested pharmaceutically. Overcoming this stumbling block in medical cannabis advancement, Vancouver-based biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) (IMLFF Profile) has developed a pioneering, high-yield biosynthesis process that enables the manufacture of all 90+ naturally occurring cannabinoids. This groundbreaking development could have an enormous impact in forwarding the efforts of other companies within the cannabis sector, including GW Pharmaceuticals (NASDAQ: GWPH), Zynerba Pharmaceuticals, Inc. (NASDAQ: ZYNE), Axim Biotechnologies, Inc. (OTCQB: AXIM) and 22nd Century Group, Inc. (NYSE: XXII).

InMed Pharmaceuticals, Inc.’s (CSE: IN) (OTCQB: IMLFF) novel approach to cannabinoid biosynthesis represents a potentially game-changing breakthrough in drug development. Many efforts by other companies to develop synthetic cannabis derivatives have failed. In comparison with other microbial platforms, InMed’s E. coli system has proven, through substantial experimentation, to be heartier and more efficient for the manufacturing of cannabinoids.

The process of naturally sourcing most cannabinoid compounds from the cannabis plant is extremely time-consuming, involving the tasks of planting, growing, harvesting and extracting. It is also very costly; can be low-yielding because of crop fluctuations; and involves various hard-to-remove impurities like pesticides, herbicides and fertilizers. Additionally, this process yields only two to three cannabinoids that can reach adequate quantities to justify the process; the remaining cannabinoid compounds are only yielded in trace amounts and are not accessible through natural sources.

While many have tried to chemically synthesize these compounds for pharmaceutical use, the chief problem with such an approach is it is usually very hard to derive cannabis compounds that are identical to the ones that occur naturally. Slight variations in structure can change both the effectiveness and safety of these compounds. The difficulty, tedium, costliness and time-consuming nature of the process is, overall, off-putting and creates a great deal of chemical waste.

The proprietary cannabinoid manufacturing process pioneered by InMed addresses this problem through biosynthesis, which is the process of utilizing naturally occurring cannabinoid DNA to produce cannabinoid compounds in a laboratory setting. The advantages of this process are multifold, resulting in:

Compounds that are identical to naturally occurring cannabinoids
Pure, individual cannabinoids that can be manufactured without the necessity of separating the many compounds from one another
A time- and cost-effective process
High quality control throughout the process thanks to production in a laboratory setting
The capability for all 90+ cannabinoids to be manufactured for the same reasonable cost
InMed is thus able to tap into the enormous medical potential of every cannabinoid, in particular the minor ones, due to this ability to access them in an economically sound way. The financial and time-consuming nature of other biosynthesis methods continue to pose stumbling blocks for other pharmaceutical companies.

Recently, InMed announced the filing of a provisional patent application—the first of many—relating to this proprietary biosynthesis program for manufacturing cannabinoids (http://nnw.fm/Z30dH). Once converted into an international Patent Cooperation Treaty (PCT) application and pursued in key jurisdictions on a global scale, this first patent application will give InMed significant commercial protection for its biosynthesis program, which is an E. coli-based expression system. This series of patent applications will particularly focus on the superiority of E. coli-based expression systems in comparison to other approaches; maximizing production of cannabinoids and related compounds through gene optimization; and additional proprietary developments and data related to InMed’s breakthrough biosynthesis program. Over time, InMed intends to actively convert this first patent filing, along with subsequent provisional patents, into national-stage filings in every major commercial jurisdiction.

InMed’s revolutionary cannabinoid biosynthesis program is one of three core assets for the company. The other two are a bioinformatics assessment tool that targets specific cannabinoids in treating key diseases and a drug development program that includes INM-750 for Epidermolysis bullosa and INM-085 for glaucoma.

InMed is assembling a strong management team to bring its biosynthesis program to commercialization. This team includes Ben Paterson, P.E., whose consulting services were recently retained by InMed (http://nnw.fm/vx1Bo). Paterson previously served as a senior engineering advisor for Eli Lilly and Company, spending 24 years in that company’s biosynthesis division. His extensive expertise will help InMed transition from pilot-scale to commercial-scale manufacturing.

The company’s management team also includes president and CEO Eric A. Adams, who is a veteran biopharmaceutical executive with extensive experience in company and capital formation, global market development, mergers and acquisitions, and licensing and corporate governance; Chief Scientific Officer Dr. Sazzad Hossain, Ph.D., M.Sc., who has more than two decades of academic and industrial experience in new drug discovery and natural health product development; Chief Medical Officer Dr. Ado Muhammed, MD, DPM, MFPM, who is a proven leader in developing cannabinoid therapies; Alexandra D.J. Mancini, M.Sc., who serves as the senior vice president of clinical and regulatory affairs and possesses more than 30 years of global biopharmaceutical R&D experience, with emphasis in clinical development and regulatory affairs; and CFO Jeff Charpentier, who is a biopharmaceutical industry veteran with more than 25 years of experience.

InMed’s breakthrough approach to cannabinoid biosynthesis has enormous potential in helping other companies in their cannabis-related drug development efforts—companies like GW Pharmaceuticals (GWPH), the company behind the world’s first prescription drug derived from the cannabis plant, Sativex®, which is approved for the treatment of spasticity due to multiple sclerosis. GWPH’s lead cannabinoid product candidate is Epidiolex®, a liquid formulation of pure plant-derived cannabidiol being developed for the treatment of a number of rare childhood-onset epilepsy disorders. Other companies include Zynerba Pharmaceuticals (ZYNE), whose product candidates are “synthetically manufactured per FDA/CGMP regulations” in an effort to “provide consistent potency and eliminate impurities in the product”; Axim Biotechnologies (AXIM), which is developing a clinical pipeline of cannabinoid-based products such as its MedChewRx™ chewing gum for the treatment of irritable bowel syndrome; and 22nd Century Group (XXII), a plant biotechnology company focused on genetic engineering and plant breeding which allows the increase or decrease of the level of nicotine in tobacco plants and the level of cannabinoids in cannabis plants. The availability of all 90+ cannabinoid compounds enabled by InMed’s process could mean the difference between success and failure in the development of drugs to treat various key diseases.

“This novel approach to the biosynthesis of cannabinoids is a game-changer for drug development,” said Dr. Vikramaditya Yadav, assistant professor of Chemical and Biological Engineering at the University of British Columbia and a co-inventor of InMed’s biosynthesis technology (http://nnw.fm/Z30dH). “The importance of producing cannabinoids that are identical to the naturally occurring compounds cannot be overstated. Many drug development efforts with synthetic derivatives have failed.”

With roadways opening up in cannabinoid research and this pioneering new access to every cannabinoid compound rather than just a few of them, the potential is virtually limitless as companies like those named pursue drug development activities within the medical cannabis field. There is no telling what breakthrough cures and treatments may emerge as a result, but it is indeed an exciting time in the burgeoning cannabis space.

For more information on InMed Pharmaceuticals, please visit: InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF)
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Oct 03, 2017 5:21 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Announces Filing of Provisional Patent for Cannabinoid-Based Pain Treatment

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced the filing of a provisional patent application in the United States for INM-405 and other unique compositions as cannabinoid-based topical therapies for the treatment of pain, marking an important step toward protection of the company’s intellectual and commercial property. “There remains a significant need in the field of analgesia for a product that can treat pain via a topical route of administration, which would reduce systemic exposure and any associated side effects,” Dr. Sazzad Hossain, chief scientific officer of InMed and a co-inventor on the newly-filed patent, stated in the news release. “InMed’s focus on non-psychoactive cannabinoids further reduces concerns regarding addiction, a key concern in pain management.” Notably, InMed’s research into the potential of non-THC cannabinoids in treating pain targets a growing need within the greater pain management market that’s been exacerbated by the recent increase in the number of prescriptions issued for highly addictive and potentially damaging opioid pain killers.
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Mon Oct 09, 2017 4:02 pm

InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Paving the Way as Biosynthesis Promises to Revolutionize Drug Development

- Forbes predicts medical marijuana sales to reach $13.3 billion by 2020
- Biotech/pharma market could surpass $20 billion by 2020, per estimates from Viridian Capital Advisors
- InMed’s biosynthesis process uses DNA and E. coli to produce cannabinoids that are identical to the 90+ found in nature
- The company’s pipeline drugs, focusing on rare dermatological diseases, glaucoma and topical pain treatments, are advancing toward clinical trials

There may be many companies exploring cannabinoid biosynthesis, but one in particular stands out. InMed Pharmaceuticals (CSE: IN) (OTCQB: IMLFF) has created a revolutionary process that is poised to impact the cannabinoid market. It’s just one of several companies mentioned in a recent industry article (http://nnw.fm/U2VMf) that are actively engaged in the race to synthesize the 90+ known cannabinoids in their natural forms.

InMed’s process involves using the genetic material of naturally occurring cannabinoids. By introducing their DNA in a controlled laboratory setting, scientists can create compounds that are identical to those found in nature. Each cannabinoid has the same chemical makeup as its natural counterpart. The difficult, expensive and time-consuming challenges of planting, growing and harvesting cannabis, and then extracting the individual cannabinoids for medical use, are greatly diminished. Biosynthesis also eliminates the need for fertilizers and pesticides that can be toxic to people and harmful to the environment.

Cultivating cannabis plants also requires a great deal of manpower, not to mention resources such as electricity and water. Biosynthesis not only promises to reduce the time and effort required to extract cannabinoids; it also has the potential to expedite drug development. InMed’s approach in this area was highlighted in a recent article (http://nnw.fm/of7K3) in which its E. coli-based biosynthesis platform and the potential ability to tap into the medial benefits of every cannabinoid are noted. The E. coli-based expression system utilizes an optimized gene construct to maximize production.

The company is exploring the potential in the dermatology field for its INM-750 drug candidate for epidermolysis bullosa. Cannabinoids have shown positive results in pre-clinical testing, addressing the major hallmarks of the disease, including wound healing, pain, itch, inflammation and antimicrobial control. Of particular note are the encouraging results that show INM-750 as having the potential to modulate keratin levels, which, if successful, may modulate the course of the disease itself, a game changer for patients and for the company. InMed is also conducting testing for its ocular treatment, INM-085 for glaucoma, and pain therapy with INM-405. Capable of reducing intra-ocular pressure and protecting nerve cells and tissues in the eye, INM-085 has a proprietary delivery system, a hydro-gel, that has been engineered as a specific delivery vehicle for ocular disease.

However, the company isn’t only being touted for its biosynthesis process and drug development. It has also developed a proprietary bioinformatics system. This computer-based drug/disease targeting tool enables researchers to identify cannabinoids suitable for treating specific conditions based on drug structures, protein-protein interactions, gene regulation, cell signaling and other biological processes. This approach has been validated in advanced pre-clinical models of disease for InMed’s several development programs.

The company’s research focus extends beyond skin, eye and pain treatments. It is also studying the potential effects of cannabinoids on nervous system disorders such as Huntington’s disease. Cannabinoid research is taking place at several institutions in respiratory science, with ongoing studies into possible asthma and chronic obstructive pulmonary disease therapies. Other advances in cannabinoid science include the potential for treating diabetes, obesity and other metabolic conditions. Thus, InMed’s biosynthesis process may play an integral role in advancing drug development both internally and with other entities by making specific compounds readily available for research and commercialization.

For more information, visit the company’s website at www.InMedPharma.com
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Oct 10, 2017 5:02 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Announces Addition of Dr. Mauro Maccarrone to Scientific Advisory Board

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced the addition of Dr. Mauro Maccarrone to its scientific advisory board. Maccarrone is professor and chair of biochemistry and molecular biology at Campus Bio-Medico, University of Rome. He also serves as director of the Laboratory of Lipid Neurochemistry of the European Center for Brain Research-IRCCS Santa Lucia Foundation in Rome. “InMed is dedicated to developing industry-leading products in diseases with high unmet medical needs. One key element in drug development is to ensure that we are working with leading scientists in the field who can contribute their in-depth knowledge to help advance our products,” Dr. Sazzad Hossain, chief scientific officer of InMed, stated in the news release. “We are very pleased to add Dr. Mauro Maccarrone and his vast experience in the field of cannabinoid research as an integral part of our Scientific Advisory Board. We look forward to working with Dr. Maccarrone to help bring drug therapies to those in need.”
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Oct 17, 2017 5:54 pm

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Provides Update on INM-405 Development

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced preclinical results in the development of INM-405 for the treatment of pain. Notably, results from the company’s studies suggest that peripheral application of certain cannabinoid compounds, alone or in combination, is effective in the treatment of craniofacial muscle pain disorders, without any observed CNS side effects. InMed suggests that this lack of side effects may position cannabinoid-based compounds as more desirable treatment options than existing systemic pain-relief administration. News of these findings follows the company’s recent filing of a provisional patent application in the United States for INM-405 and other unique compositions as cannabinoid-based topical therapies for the treatment of pain, which marked an important step in InMed’s efforts to protect its intellectual and commercial property.
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Thu Oct 19, 2017 4:44 pm

InMed Pharmaceuticals, Inc.’s (CSE: IN) (OTCQB: IMLFF) Biosynthesis Technology Demonstrates Robust Diversity

- Biosynthesis technology making strong advances
- Two promising pipeline candidates
- Inclusion in the CSE25 Index

InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) continues down the fast track with its proprietary technology for the microbial biosynthesis of cannabinoids (http://nnw.fm/tP4jS). The company recently announced it has enabled the production of all four “gateway” cannabinoids using genetically engineered microorganisms. From these gateway substrates, production of all 90+ cannabinoids is possible via biosynthesis. InMed’s breakthrough stands to make the production of cannabis derivatives, including THC, CBD and trace cannabinoids, a much more commercially feasible proposition. The Company currently has two lead drug candidates that employ combinations of cannabinoids as the active ingredients. Moreover, as if to put a seal on its step forward, InMed is now included in the CSE25 Index, since it is now one of the twenty-five largest companies in the CSE Composite Index.

To date, over 90+ different cannabinoids have been isolated from the Cannabis sativa plant, the two best known being delta-9-tetrahydrocannabinol (THC), which is responsible for the ‘high’ derived from marijuana, and cannabidiol (CBD). Research into their pharmacological properties has shown that cannabinoids are not all created equally, however: some matter more than others, from a manufacturing process point-of-view. Four key gateway cannabinoids hold the door through which all others must pass: CBGA, CBNA, CBGV, and CBGVA. Following the most prevalent synthesis pathway in the plant, CBGA is formed from precursors; downstream enzymes then determine if CBGA diversifies to become tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromene acid (CBCA), or cannabigerol (CBG). Then, further reactions by synthases give rise to a multitude of the most common cannabinoids that so richly endow the plant, including THC and CBD.

InMed’s progress brings scale-up and commercialization of its disruptive biosynthesis process closer to fruition. Traditionally, sourcing cannabinoids has been accomplished by growing, harvesting, processing and purifying (via extraction) the cannabis plant. The extraction process can be expensive, and can result in unwanted by-products and impurities. Biosynthesis mimics the cannabinoid-creation process found in plants by utilizing a microbial host, resulting in pure, individual cannabinoids that will be devoid of the by-products and impurities seen with extraction. The InMed approach is to introduce cannabinoid DNA into E. coli bacteria that results in a biofermentation process, enabling a laboratory-based process under tightly controlled conditions. The process can be tailored to produce any of the 90+ “downstream” cannabinoids found naturally in the cannabis plant. InMed’s biosynthesis program will provide an alternative to the agricultural approach in a low cost and high quality process. Currently, the Company is actively employing this production chassis to biosynthesize compounds for its pharmaceutical research programs. The possibilities of future growth opportunities are expanded significantly as InMed’s proprietary process may serve as foundation to supply cannabinoids to the pharmaceutical, nutraceutical, medical marijuana and even recreational sectors. What is the potential size of this market? GreenWave Advisors has stated the market for a single cannabinoid, CBD, could grow to $3 billion by 2021 in the US. alone.

Further signaling its rising fortune, InMed has announced (http://nnw.fm/8cO99) it is now part of the CSE25 Index, qualifying for the index as one of the twenty-five largest companies by market capitalization on the Canadian Stock Exchange (CSE).

InMed currently has two lead candidates in its drug pipeline. The first, INM-750, is for the treatment of a rare genetic skin disorder, called epidermolysis bullosa (EB), affecting roughly one out of every 20,000 births in the United States. The condition, which currently has no approved treatment or cure, has been called “The Worst Disease You’ve Never Heard Of” by the Dystrophic Epidermolysis Bullosa Research Association of America. INM-750 works two ways. First, it addresses the primary hallmarks of the disease: wound-healing, pain, inflammation, itch, and infection. Second, this compound may have the potential to reverse the course of the disease itself in some patients by upregulating compensatory keratins in the skin to replace defective ones.

The second candidate is INM-085 for the treatment of glaucoma, a leading cause of blindness, according to the Glaucoma Research Foundation. The drug reduces the elevated intra-ocular pressure that is often associated with glaucoma. It is targeting a large market. The National Institutes of Health estimates that more than 3 million Americans currently have glaucoma.

For more information, visit the company’s website at www.InMedPharma.com
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Tue Oct 24, 2017 5:08 pm

How Biosynthesis is Revolutionizing Cannabinoid Pharmaceuticals

NetworkNewsWire Editorial Coverage: The potential of cannabis for the treatment of an array of medical conditions is a hot topic, and, while many states in America have legalized the use of marijuana in one form or another, the Food and Drug Administration (FDA) is loath to approve drugs from this source. The FDA has concerns with the consistency of drugs extracted from marijuana, and current Good Manufacturing Practices (GMP) regulations are difficult to implement with naturally-sourced products, dissuading most pharmaceutical companies from pursuing this avenue. A possible solution to the FDA’s concern with quality and consistency lies in the biosynthesis of cannabinoids. Biosynthesis gives manufacturers the ability to produce a high-quality and consistent active ingredient every time, eliminating concerns of crop variability and pesticide contaminants while greatly reducing cost. InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) (IMLFF Profile) stands out as a unique biotech drug development company in this regard, positioning it among the ranks of bigger companies like Zynerba Pharmaceuticals, Inc. (NASDAQ: ZYNE), a clinical-stage pharmaceutical company developing proprietary synthetic (chemistry-based) cannabinoid treatments for transdermal delivery, and GW Pharmaceuticals plc (NASDAQ: GWPH), which is also at the forefront of pre-clinical research and development of cannabinoids that are extracted from plants. Canopy Growth Corp. (OTC: TWMJF) (TSX: WEED) and Aurora Cannabis, Inc. (OTCQX: ACBFF) (TSX: ACB) are major suppliers of high-quality, medical-grade marijuana, which is critical for many biotech companies who need a source of plant-based starting materials.

The issue is that plant-based processes (planting, growing, harvesting, extracting and purifying) result in active ingredients at varying concentration levels with inconsistent qualities, including impurities such as pesticides. Companies interested in this approach for their products need to establish vast and high-volume marijuana greenhouse growing operations. This is a huge expense, further compounded by the complex process to produce pharmaceutical grade cannabinoids that meet the GMP requirements for FDA approval. InMed Pharmaceuticals (CSE: IN) (OTCQB: IMLFF) has taken the inside track in the industry and has just completed the world’s first-ever recorded study that successfully stitched together several key components in the drug development continuum for cannabinoid therapies, including:

biosynthesizing a cannabinoid;
packaging the cannabinoid as a nanoparticle;
formulating the nanoparticles into a novel tissue-specific delivery vehicle;
and confirming delivery and diffusion into the target tissue.
This study is significant in validating InMed’s wide spectrum of cannabinoid know-how for pharmaceutical development, which ranges from discovery and manufacturing to formulation and delivery. Whereas other companies are in the process of researching or testing only the two main cannabinoids found in marijuana (THC and CBD), InMed is using its proprietary bioinformatics and manufacturing process to research the physiological impact of all 90+ cannabinoids found in the plant. The company’s biosynthesis process results in pharmaceutical grade (>95%) purity and is bioidentical to the plant’s cannabinoids. Importantly, by making individual cannabinoid compounds, InMed can avoid any contamination by tetrahydrocannabinol (THC) – the mind-altering chemical in the cannabis plant – and, therefore, InMed products will have no psychoactive properties.

Building on this capability, InMed has also achieved an industry first with its development of a cannabinoid nanoparticle hydrogel as the delivery mechanism for its INM-085 candidate, which is formulated to treat glaucoma by reducing elevated intra-ocular pressure and providing protection to the retinal nerves. Glaucoma treatment is usually administered via eyedrops, which are typically washed away immediately due to blinking. As a result, patient compliance with their drug administration schedules is poor in this disease. A hydrogel delivery mechanism, however, has a huge advantage in that it forms a medicated gel-like lens over the eye. INM-085 is intended as a once-per-day eyedrop administered immediately prior to the patient’s bedtime, intending to assist in reducing the high rate of non-compliance and to maximize drug absorption from a single drop.

Following this success, InMed is scaling its manufacturing process and pursuing research into other medical conditions by leveraging its know-how in cannabinoid drug development. Because biosynthesized cannabinoids are identical to those found in nature, they have potentially fewer adverse events associated with varying drug structures and may confer better efficacy. Biosynthesis also avoids several of the drawbacks associated with growing marijuana, including elimination of pesticides that can be toxic to people and harmful to the environment.

As favorable evidence of cannabis for therapeutic applications expands, the medicinal marijuana market continues to swell with innovation. Much focus is placed on biotechs, such as InMed, that are actively engaged in the development of cannabinoids for various therapeutic applications. Notably, InMed has a significant advantage in its ability to create biosynthetic cannabinoids in a controlled laboratory setting. The company’s breakthrough approach to cannabinoid biosynthesis has incredible potential in helping other companies with their cannabis-related drug development efforts.

Another company deeply invested in the manufacturing of synthetic (chemistry-based) cannabinoids is Zynerba Pharmaceuticals (NASDAQ: ZYNE). The clinical-stage pharmaceutical company is focused on developing proprietary synthetic cannabinoid treatments designed for transdermal delivery and targeting patients with unmet medical needs. Zynerba is currently working on two products: a synthetic CBD gel for patients with osteoarthritis, epilepsy and Fragile X syndrome, and a synthetic THC transdermal patch targeting fibromyalgia and peripheral neuropathic pain. With a market cap of $128 million (as of October 20, 2017) and a recent stock price surge following the announcement of positive results from a clinical study into the effects of its transdermal CBD gel on pediatric and adolescent patients with Fragile X syndrome, Zynerba looks set to become a leading synthetic CBD manufacturer and a highly attractive investment opportunity on the fast-growing cannabinoid-based pharmaceutical market.

Cannabinoid synthesis or biosynthesis can have a highly positive impact on companies such as GW Pharmaceuticals (NASDAQ: GWPH), which has developed commercial-stage cannabinoid products for both orphan and non-orphan indications in neurological conditions. The company also created a CBD product for the treatment of certain epilepsy syndromes and developed the world’s first cannabis-based prescription medicine for the treatment of spasticity in sufferers of multiple sclerosis. While it is a leading cannabis biotech in terms of market cap ($2.7 billion as of October 23, 2017), without the ability to create biosynthetic cannabinoids in-house, GW Pharmaceuticals outsources the cultivation of cannabis for its products to UK-based British Sugar. Though British Sugar’s crop yield is expected to support the development of GW Pharmaceutical’s childhood epilepsy drug, the cultivation comes at considerable expense due to electricity, lighting, heating, real estate, manpower and other resources.

Other biotech companies turn to the green fields in Canada, where roughly 38 licensed cannabis producers are scrambling to keep up with the demand for legalized medicinal marijuana and impending demand for recreational marijuana (expected to be legalized July 2018).

Currently Canada’s largest producer of marijuana, Canopy Growth Corp. (OTC: TWMJF) (TSX: WEED) has over half a million square feet of greenhouse cannabis capacity and has committed to developing 1.3 million square feet of greenhouse growing capacity in British Columbia. The company is partnered with Bedrocan BV, a company based in Holland, to produce and distribute medical-grade cannabis via one of its core brands, Bedrocan Canada, demonstrating the need for high quantities of medicinal-grade cannabis. Due to its consistently high quality, Canopy Growth’s products are used extensively in clinical research in several European countries. In addition, the company recently launched the EQUAL Study to evaluate the effects of medical cannabis use on quality of life. Notably, this is one of the largest marijuana studies in the world.

In August, Canopy Growth reported first quarter fiscal 2018 revenue of C$15.8 million, marking a year-over-year increase of 127.4 percent and an increase of 8 percent compared to the fourth quarter of fiscal 2017 revenues.

“Our focus in the first half of calendar 2017 has been preparing our business to lead the legal recreational market that is set to open in Canada in 2018, while continuing to be the clear leader in the ongoing medical market,” Canopy Growth chairman and CEO Bruce Linton stated in the earnings release.

Another cultivator benefitting from most biotech companies’ need for cannabis products is Canada-based Aurora Cannabis (OTCQX: ACBFF) (TSX: ACB), a leading producer and distributor of medical cannabis. The company also operates a portal for registered physicians and patients that makes it easier to prescribe and fill prescriptions. Aurora recorded fourth-quarter 2017 revenues of $5.9 million, citing growth in patient numbers and an increase in the average price per gram of product sold, which now includes high-margin cannabis oils. Also in the fourth quarter, Aurora acquired Peloton Pharmaceuticals, including a 40,000-square-foot facility that, upon completion, is expected to generate its first harvest shortly after calendar-year end.

With the successful development of its biosynthetic cannabinoid for the treatment of glaucoma, InMed continues to make strides down the pathway toward making biosynthesized cannabinoid pharmaceutical products a reality. The company opened the door to further developments in the application of cannabinoids for many other therapies.

For more information on InMed Pharmaceuticals, please visit: InMed Pharmaceuticals, Inc. (CSE: IN)
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Re: InMed Pharmaceuticals, Inc. (IMLFF)

Postby QualityStocks » Wed Oct 25, 2017 3:14 am

NetworkNewsBreaks – InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) Highlights Positive Pre-Clinical Data Related to Biosynthesis Platform

Preclinical stage biopharmaceutical company InMed Pharmaceuticals, Inc. (CSE: IN) (OTCQB: IMLFF) this morning announced results from a study co-sponsored by InMed and the University of British Columbia. Notably, this study is the first ever to report hydrogel-mediated cannabinoid nanoparticle delivery to the eye resulting in enhanced drug uptake via the cornea and lens. “Importantly, this study offers further validation of InMed’s capabilities in moving the science of cannabinoid pharmaceuticals forward,” Eric A. Adams, president and CEO of InMed, stated in the news release. “Results like this, combined with our expanding patent portfolio and list of publications, on-going R&D, and renowned scientific team and collaborators demonstrates our depth of know-how and supports our trajectory to becoming an industry leader.” Per this morning’s update, the study also validated InMed’s capacity to conduct a wide spectrum of drug development activities, including biosynthesis of a cannabinoid using a novel E. coli-based system, packaging of the cannabinoid as a nanoparticle, formulation of a cannabinoid drug candidate into a novel, tissue specific delivery vehicle and confirmation of drug delivery and diffusion into a target tissue.
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